Weight loss, in the context of   medicine, health or physical fitness, is a reduction of the total body   mass, due to a mean loss of fluid, body fat or adipose tissue and/or   lean mass, namely bone mineral deposits, muscle, tendon and other   connective tissue. It can occur unintentionally due to an underlying   disease or can arise from a conscious effort to improve an actual or   perceived overweight or obese state. 
       
       
      Unintentional weight loss 
       
       
      Unintentional weight loss occurs in   many diseases and conditions,including some very serious diseases such   as cancer, AIDS, and a variety of other diseases. 
       
       
      Poor management of type 1 diabetes   mellitus, also known as insulin-dependent diabetes mellitus (IDDM),   leads to an excessive amount of glucose and an insufficient amount of   insulin in the bloodstream. This triggers the release of triglycerides   from adipose (fat) tissue and catabolism (breakdown) of amino acids in   muscle tissue. This results in a loss of both fat and lean mass, leading   to a significant reduction in total body weight. Note that untreated   type 1 diabetes mellitus will usually not produce weight loss, as these   patients get acutely ill before they would have had time to lose weight. 
       
       
      In addition to weight loss due to a   reduction in fat and lean mass, illnesses such as diabetes, certain   medications, lack of fluid intake and other factors can trigger fluid   loss. And fluid loss in addition to a reduction in fat and lean mass   exacerbates the risk for cachexia. 
      Infections such as HIV may alter metabolism, leading to weight loss. 
      Hormonal disruptions, such as an overactive thyroid (hyperthyroidism), may also exhibit as weight loss. 
      Recent research has shown fidgeting to result in significant weight loss 
      
      
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